(PharmaNewsWire.Com, July 24, 2024 ) InsightAce Analytic Pvt. Ltd. announces the release of a market assessment report on the "Global GLP-1 Market Size, Share & Trends Analysis Report By Type of Molecule (Biologics and Small Molecules), Active Compound Used (Dulaglutide, Liraglutide, Orforglipron, Retatrutide, Semaglutide, Survodutide, Tirzepatide and Other Active Compounds), Type of GLP-1 Agonist Drugs (Long-acting GLP-1 Agonist and Short-acting GLP-1 Agonist), Type of Agonist (Single-agonist, Dual-agonist and Tri-agonist), Route of Administration (Oral and Parenteral), Target indication (Alzheimer’s Disease, Non-Alcoholic Steatohepatitis, Obesity, Sleep Apnea, Type 2 Diabetes)- Market Outlook And Industry Analysis 2031"
Glucagon-like peptide-1 (GLP-1) is a gut-produced hormone essential for regulating blood sugar levels and appetite. GLP-1 receptor agonists are medications that activate the GLP-1 receptor, resulting in several beneficial effects, including enhancing insulin secretion from pancreatic beta cells in response to elevated glucose, reducing glucagon secretion, slowing gastric emptying, and improving glucose disposal in peripheral tissues. These functions make GLP-1 receptor agonists particularly valuable in managing type 2 diabetes by effectively lowering blood sugar levels and promoting weight loss, which is crucial for many diabetic patients. Additionally, some GLP-1 agonists have gained approval for obesity treatment due to their appetite-suppressing and weight-loss-inducing properties. The GLP-1 receptor agonist market features a variety of approved and investigational products, including short-acting agonists like exenatide and lixisenatide, long-acting options such as semaglutide, dulaglutide, and liraglutide, as well as oral formulations like oral semaglutide (Rybelsus). There are also dual and tri-agonists like tirzepatide, which target multiple receptors. The rising prevalence of diabetes and obesity, combined with the proven efficacy and safety of GLP-1 receptor agonists, has fueled substantial market growth. As pharmaceutical innovation continues to broaden the GLP-1 agonist landscape, this segment is expected to experience further expansion in the coming years.
List of Prominent Players in the GLP-1 Market: • AstraZeneca • Biolingus • Boehringer Ingelheim • D&D Pharmatech • Eli Lilly • Gmax Biopharm • Hanmi Pharmaceutical • Innogen • Novo Nordisk • PegBio • Pfizer • QL Biopharma • Roche • Sanofi • Sciwind Biosciences • Tonghua Dongbao Pharmaceutical • Viking Therapeutics • Vivani • vTv Therapeutic
Market Dynamics:
Drivers- The rising global prevalence of type 2 diabetes and obesity is a significant driver of growth in the GLP-1 receptor agonist market, with diabetes rates increasing from 3% to 4.1% and obesity rising from 32.7% to 40.9% between 2009 and 2020, according to a study published in the Journal of the American Medical Association. GLP-1 receptor agonists have shown strong efficacy in lowering blood sugar levels, reducing HbA1c, and promoting substantial weight loss in affected patients. Recent regulatory approvals for treatments like semaglutide (Wegovy) for obesity, in addition to diabetes, have broadened the patient base and further fueled market expansion. Improved insurance coverage and affordability are making these treatments more accessible, while continuous pharmaceutical innovation—including the launch of oral and once-weekly injectable formulations—enhances patient convenience and adherence, addressing unmet healthcare needs.
Challenges: GLP-1 receptor agonists face challenges impacting patient adherence, including gastrointestinal side effects like nausea and vomiting, which can deter use. Many require subcutaneous injections, posing convenience issues, though oral options like semaglutide are emerging. While long-acting formulations offer once-weekly dosing, there's a need for even less frequent administration. Additionally, high costs and limited insurance coverage, especially in developing markets, restrict access, underscoring the importance of improving affordability.
Regional Trends: The APAC region is rapidly emerging as a significant market for GLP-1 receptor agonists, driven by countries such as China, Japan, and India. This growth is supported by an expanding healthcare sector, a large target patient population, and substantial unmet clinical needs for diabetes and obesity treatments. The increasing prevalence of type 2 diabetes and obesity in APAC countries is fueling demand for effective GLP-1 therapies. Additionally, major pharmaceutical companies are focusing on innovative GLP-1 receptor agonist solutions to meet the region's growing healthcare needs.
Recent Developments: • In November 2023, The U.S. Food and Drug Administration (FDA) has approved Eli Lilly and Company's Zepbound™ (tirzepatide) injection, marking it as the first and only obesity treatment that activates both GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) hormone receptors. • In Dec 2021, Shanghai Innogen Pharma successfully completed a $120 million Series A funding round to support its Phase III trial of supaglutide, a GLP-1 agonist targeting diabetes. The funds will also be used to advance several first-in-class programs and establish a clinical trial manufacturing facility.
Segmentation of GLP-1 Market-
By Type of Molecule: • Biologics • Small Molecules
By Active Compound Used: • Dulaglutide • Liraglutide • Orforglipron • Retatrutide • Semaglutide • Survodutide • Tirzepatide • Other Active Compounds
By Type of GLP-1 Agonist Drugs: • Long-acting GLP-1 Agonist • Short-acting GLP-1 Agonist
By Type of Agonist: • Single agonist • Dual agonist • Tri-agonist
By Route of Administration: • Oral • Parenteral
By Target Indication: • Alzheimer’s Disease • Non-Alcoholic Steatohepatitis • Obesity • Sleep Apnea • Type 2 Diabetes
By Region- North America- • The US • Canada • Mexico Europe- • Germany • The UK • France • Italy • Spain • Rest of Europe Asia-Pacific- • China • Japan • India • South Korea • Southeast Asia • Rest of Asia Pacific Latin America- • Brazil • Argentina • Rest of Latin America Middle East & Africa- • GCC Countries • South Africa • Rest of Middle East and Africa
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