Skin substitutes are natural, synthetic or biosynthetic materials, used to cover large wounds to restore at least some of the functions of the skin. Skin substitutes provides temporary or permanent wound closure and protect the wound from infection, further damage and water loss, and reduce pain. They also facilitate the growth of the normal skin over the wound.
Skin substitutes provide a permanent solution and are used in the treatment of conditions like burns, trauma wounds, diabetes or venous ulcers, where skin grafts may not be possible.
Rising chronic skin diseases is expected to drive the Skin Substitutes Market. For instance, according to the global burden of disease study 2013, Skin conditions contributed around 1.79% to the global disease burden. According to the World Health Organization, about 132,000 melanoma skin cancers occur each year worldwide. Thus, the rising chronic diseases is increasing the demand for skin substitutes in the forecast period.
There are several limitations to the commercially available skin substitutes, like reduced vascularization, poor mechanical integrity, failure to integrate, scarring, and immune rejection.
The collective revenue of acellular sub-segment is expected to generate USD XX Mn during 2019-2026.
Rise in preference for acellular skin substitutes to implant-based skin surgery is expected to drive the growth of the Skin Substitutes Market. For instance, the American Society of Plastic Surgeons in 2012, reported that more than 50% surgeons in the US has preferred acellular matrix for skin surgeries. Also, the rising incidence rate of skin disorders across the globe may lead to an increased number of patients who will undergo either invasive or non-invasive skin surgeries. For instance, according to the American Academy of Dermatology in 2013, one in five persons in the US is expected to develop skin disorders in their lifetime.
The collective revenue of burn injuries-segment is expected to generate USD XX Mn during 2019-2026. Rising incidences of burn injuries is expected to drive the market. For instance, according to the World health organization, an estimated 180 000 deaths every year are caused by burns – the vast majority occur in low- and middle-income countries. Also, the presence of novel approaches in the treatment of burns is expected to drive the market. For instance, 3D bioprinting, a transformative technology for the reconstruction of burn wounds is the recent approach which enables accurate placement of cell types and allows precise and reproducible fabrication of constructs which replaces the injured or damaged sites. Thus, its use for wound reconstruction will lead to a paradigm shift in patient outcomes.
Geographically, the market is divided into North America, Europe, South America, Asia-Pacific and the Middle East and Africa.
North America holds the major market share for skin substitutes in 2018, due to the increasing incidences of burns and chronic skin diseases. Rising cases of burns is expected to drive the market over the period of forecast. For instance, according to world health organization, in 2008, over 410 000 burn injuries occurred in the US, with approximately 40 000 requiring hospitalization.
According to American burn association in 2016, over 60% of the estimated US acute hospitalizations related to burns were admitted to 128 burn centers. Also, the healthcare burden in 2000, which includes direct costs for care of children with burns in the United States of America exceeded US$ 211 million.
Some of the major players include Amarantus BioScience Holdings, Organogenesis, Inc., Acelity L.P., Inc., Smith & Nephew plc, BSN Medical, Molnlycke Health Care, Integra LifeSciences Corporation.
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