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New Study Reveals Gene Therapies: A Diverse Range of Technologies with a Promising Long-Term Outlook

(PharmaNewsWire.Com, January 10, 2017 ) "Gene Therapies: A Diverse Range of Technologies with a Promising Long-Term Outlook"" discusses all gene therapies under the broad criteria of genetic material introduced to the cell for a therapeutic purpose. It includes not only the insertion of a gene into the cell for expression, but also gene silencing with RNA interference (RNAi) and antisense RNA, aptamers (DNA or RNA polymers which bind to a protein target), and oncolytic viruses.

Gene therapies have been in development in humans for 25 years, and a number of products have begun to enter the pharmaceutical market. However, due to various challenges and clinical trial setbacks, progress in developing this technology and achieving suitability for commercial usage has been slow. Gene therapies only account for a marginal market share and many efficacy and safety concerns remain unaddressed. However, the pipeline is robust; 906 pipeline gene therapies are currently in development. Most are at an early stage of development, with 76% at the Discovery or Preclinical stage. However, there are currently 23 gene therapy programs in Phase III development and two at the Pre-registration stage. This indicates that although gene therapies are beginning to reach the market after two decades of research in humans, the majority remain in relatively early development.

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This CBR report provides a comprehensive view of the clinical, R&D, commercial and competitive landscape of Gene Therapy, and assesses key developments in delivery vector technology, and challenges and advances associated with the production of such vectors.

Scope

Despite 25 years of clinical research, only a few gene therapies of all types have reached the market globally, and none have achieved strong clinical or commercial success

Table of Content

Gene Therapy Overview
Types of Gene Therapy
Types of Intervention
Types of Vector
Currently Approved Gene Therapies
Glybera (alipogene tiparvovec)
Kynamro (mipomersen)
Macugen (pegaptanib)
Vitravene (fomivirsen)
Gendicine (rAd-p53)
Oncorine (rAd5-H101)
Neovasculgen (Pl-VEGF165)
Gene Therapy Production Strategies
Production of Viral Vectors
Case Study: Challenges in the Manufacture of AAV Vectors
Challenges to Gene Therapy Development
Gene Therapy Pipeline
Gene Therapy Pipeline by Therapy Area and Stage of Development
Gene Therapy Pipeline by Intervention and Vector Type
Company Positioning
Companies by Therapy Area
Companies by Stage of Development
Companies by Intervention Type
Companies by Vector Type
Conclusion

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